Nembutal Phenobarbital 100mg is clinically indicated for:
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Management of refractory insomnia (short-term)
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Pre-anesthetic sedation
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Acute seizure control
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Emergency treatment of status epilepticus
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Palliative sedation in terminal care (under strict medical supervision)
Pharmacological Profile
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Classification: Barbiturate (Schedule IV controlled substance)
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Bioavailability: 80-90% (oral administration)
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Peak Effect: 30-60 minutes post-administration
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Elimination Half-life: 53-118 hours (dose-dependent)
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Primary Action: GABA-ergic neurotransmission enhancement
Dosage Protocol
Standard Adult Dosing:
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Sedative-Hypnotic: 100-200mg at bedtime
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Preoperative: 100-300mg 1-2 hours pre-procedure
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Anticonvulsant: 200-400mg loading dose (medical supervision required)
Critical Administration Guidelines:
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Swallow capsule whole with water
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Administer on empty stomach for faster absorption
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Strict adherence to prescribed regimen mandatory
Black Box Warnings
High Risk of:
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Life-threatening respiratory depression
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Severe physical/psychological dependence
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Potentially fatal overdose (especially with concurrent CNS depressants)
Contraindications
Absolute Contraindications Include:
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Acute intermittent porphyria
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Severe hepatic impairment
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History of barbiturate addiction
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Concurrent use of other respiratory depressants
Adverse Effect Profile
Frequent (≥5%):
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Cognitive impairment
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Motor coordination deficits
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Mild hypotension
Severe (Require Immediate Intervention):
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Apnea
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Cardiovascular collapse
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Severe cutaneous reactions
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Paradoxical CNS excitation
Critical Drug Interactions
Hazardous Combinations:
All opioid analgesics
Ethanol-containing products
Other GABA-ergic agents
CYP450 inducers/inhibitors
Risk Mitigation Strategies
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Mandatory respiratory monitoring in clinical settings
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Strict adherence to prescribed dosing intervals
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Comprehensive patient education on overdose signs
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Regular hepatic function monitoring with prolonged use
Regulatory Information
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DEA Scheduling: Schedule IV Controlled Substance
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Prescription Requirements:
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Written prescription only (no refills)
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Physician DEA registration mandatory
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State-specific controlled substance regulations apply
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Storage Protocol:
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Temperature-controlled environment (15-30°C)
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Secure, limited-access storage
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Inventory control per DEA requirements