Nembutal Phenobarbital 100mg Tablets

Buy Nembutal Phenobarbital

Nembutal Phenobarbital 100mg is clinically indicated for:

• Management of refractory insomnia (short-term)

• Pre-anesthetic sedation

• Acute seizure control

• Emergency treatment of status epilepticus

• Palliative sedation in terminal care (under strict medical supervision)

Pharmacological Profile

• Classification: Barbiturate (Schedule IV controlled substance)

• Bioavailability: 80-90% (oral administration)

• Peak Effect: 30-60 minutes post-administration

• Elimination Half-life: 53-118 hours (dose-dependent)

• Primary Action: GABA-ergic neurotransmission enhancement

Dosage Protocol

Standard Adult Dosing:

• Sedative-Hypnotic: 100-200mg at bedtime

• Preoperative: 100-300mg 1-2 hours pre-procedure

• Anticonvulsant: 200-400mg loading dose (medical supervision required)

Critical Administration Guidelines:

• Swallow capsule whole with water

• Administer on empty stomach for faster absorption

• Strict adherence to prescribed regimen mandatory

Black Box Warnings

High Risk of:

• Life-threatening respiratory depression

• Severe physical/psychological dependence

• Potentially fatal overdose (especially with concurrent CNS depressants)

Contraindications

Absolute Contraindications Include:

• Acute intermittent porphyria

• Severe hepatic impairment

• History of barbiturate addiction

• Concurrent use of other respiratory depressants

Adverse Effect Profile

Frequent (≥5%):

• Cognitive impairment

• Motor coordination deficits

• Mild hypotension

Severe (Require Immediate Intervention):

• Apnea

• Cardiovascular collapse

• Severe cutaneous reactions

• Paradoxical CNS excitation

Critical Drug Interactions

Hazardous Combinations:
All opioid analgesics
Ethanol-containing products
Other GABA-ergic agents
CYP450 inducers/inhibitors

Risk Mitigation Strategies

• Mandatory respiratory monitoring in clinical settings

• Strict adherence to prescribed dosing intervals

• Comprehensive patient education on overdose signs

• Regular hepatic function monitoring with prolonged use

Regulatory Information

• DEA Scheduling: Schedule IV Controlled Substance

• Prescription Requirements:

  • Written prescription only (no refills)

  • Physician DEA registration mandatory

  • State-specific controlled substance regulations apply

Storage Protocol:

• Temperature-controlled environment (15-30°C)

• Secure, limited-access storage

• Inventory control per DEA requirements

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